دانلودمقاله باموضوع مطالعه آزمایشی ایمنی و کارایی درمان قلیایی بر عملکرد عروقی در گیرندگان پیوند کلیه
در قالب pdf و در 8 اسلاید،قابل ویرایش، شامل:
موضوع به انگلیسی:A Pilot Study of the Safety and Efficacy
of Alkali Therapy on Vascular Function
in Kidney Transplant Recipients
بخشی از متن:Metabolic acidosis is associated with cardiovascular events, graft function, and mortality in
kidney transplant recipients (KTRs). We examined the effect of alkali therapy on vascular endothelial
function in KTRs.
Methods: We performed an 18-week, randomized, double-blind, placebo-controlled crossover pilot study
examining the effect of sodium bicarbonate therapy versus placebo on vascular function in 20 adult KTRs
at least 1 year from transplant with an estimated glomerular filtration rate (eGFR) $45 ml/min per 1.73 m2
and a serum bicarbonate level of 20 to 26 mEq/L. Each treatment period was 8 weeks in duration with a 2-
week washout period between treatments. The primary outcome was change in brachial artery flowmediated
dilation (FMD) between sodium bicarbonate treatment and placebo.